Los distintos grupos de trabajo del IDEHU publican periódicamente los resultados de sus investigaciones, así como trabajos de revisión, en diversas revistas científicas internacionales. Estos publicaciones se dan tanto en el área de la Inmunología (nuestra área de referencia) como en otras, incluyendo Endocrinología, Biología Estructural, Oncología, Toxicología, Fotobiología, entre otras.
Se detallan a continuación las publicaciones de los últimos dos años.
Trabajos Publicados
- Antonoglou MB, Sánchez Alberti A, Redolfi DM , Bivona AE, Noli Truant S, Sarratea MB, Cardoso AC, Motta FN, Malchiodi EL, Fernández MM. “Protective immunity against Chagas disease induced by a superantigen-based chimeric DNA vaccine delivered by attenuated Salmonella”. Frontiers in Immunology, https://doi.org/10.3389/fimmu.2026.1788924 2026.
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Evaluation of a competitive ELISA for detecting the anti-Brucella antibodies in serum and milk of goats and cattle. Foster CN, Rossi UA, Saracino MP, Ferrero MC, Baldi PC, Rossetti CA. Veterinary Research Communications 50:86, 2026. ISSN 1573-7446. FI 2024: 2.0 (Q1). https://doi.org/10.1007/s11259-025-11029-8.
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A 3D Organotypic Human Bronchial Model Reveals Persistent Infection and Modulated Inflammatory Response when Exposed to Brucella abortus.Alonso Paiva IM, Muñoz González F, Rotondaro C, Bialer M, Arias P, Kierbel A, Ferrero MC, Baldi PC. Tropical Medicine and Infectious Disease. 2026; 11(3):78.
PUBLICACIONES
- Muñoz González F, Bialer MG, Cerutti ML, Estein SM, Ramis L, Baldi PC, Zorreguieta A, Ferrero MC. Brucella suis ∆mapB outer membrane vesicles as an acellular vaccine against systemic and mucosal B. suis infection. Frontiers in Immunology 15:1501791, 2025. https://doi.org/10.3389/fimmu.2024.1501791.
- Zavattieri L, Macchi R, Canellada AM, Pibuel MA, Poodts D, Ferrero MC, Baldi PC. Brucella-induced impairment of decidualization and its impact on trophoblast function and inflammatory profile. International Journal of Molecular Sciences 26:8189, 2025. https://doi.org/10.3390/ijms26178189.
- Vila CC, Saracino MP, Pallaro AN, Baldi PC. Impact of malnutrition on the course of helminth infection and the associated immune response. Nutrition Reviews (en prensa). https://doi.org/10.1093/nutrit/nuaf229
- J.I. Marfía, I. Smith, A.M. Targovnik, F.A. Di Lello, F.J. Wolman, D.M. Flichman, M.V. Miranda*, S.N. Valdez*. Development and validation of dengue virus envelope protein domain III IgG antibody enzyme-linked immunosorbent assay.*These authors contributed equally to this work. Journal of Immunological Methods 542 (2025) 113887 https://doi.org/10.1016/j.jim.2025.113887
- Pamela A. Kuhlmann; Dante L. Di Nucci; Silvina N. Valdez; Juan I. Marfia; Ignacio Smith; María V. Miranda; Candelaria Sanchez Fernandez; Emanuel Grassi; Erik Ruuth; Karina A. Salvatierra. SARS-CoV-2 Antibodies in Wild Mammals from Atlantic Forest Region in Misiones province, Argentina. J Wildl Dis (2025) https://doi.org/10.7589/JWD-D-25-00003
- I.C. Llanos, M.C. Maselli, S.N. Valdez. Actualización: Péptido C. Estado actual de su medición. Revista de la Sociedad Argentina de Diabetes Vol. 59 Nº 3. Septiembre-diciembre de 2025: 172-175 ISSN 0325-5247 (impresa) ISSN 2346-9420 (en línea).
- L. Trifone, M. Ferraro, S. Valdez, G. Frechtel, L. Caratcoche. Recomendaciones en predicción de diabetes mellitus tipo 1. Detección, estadificación y estrategias para preservar la función de las células beta en niños, niñas y adolescentes con diabetes tipo 1. Recomendaciones de la Sociedad Argentina de Diabetes. Revista de la Sociedad Argentina de Diabetes Vol. 59 Nº 3 Septiembre-diciembre de 2025: 176-192 ISSN 0325-5247 (impresa) ISSN 2346-9420 (en línea)
- S.S. Bombicino*, A. Trabucchi*, A.V. Sabljic, J.I. Marfía, R.F. Iacono, and S.N. Valdez*Both authors contributed equally. Development of a novel Flow Cytometry Multiplex Immunoassay for the diagnosis of Celiac Disease simultaneously with Autoimmune Diabetes. Aceptado para su publicación en European Journal of Medical Research, Noviembre 2025
- Zavattieri L, Macchi R, Canellada AM, Pibuel MA, Poodts D, Ferrero MC, Baldi PC. Brucella-induced impairment of decidualization and its impact on trophoblast function and inflammatory profile. International Journal of Molecular Sciences 26:8189, 2025. https://doi.org/10.3390/ijms26178189.
- Garimano N, Aguayo Frías T, González Maglio DH. Beyond ultraviolet radiation: Immune system modulation through skin exposure to visible light and infrared radiation. Photochem Photobiol. 2025 Jul-Aug;101(4):846-857. doi: 10.1111/php.14117. Epub 2025 May 16. PMID: 40376965.
- Puca G, Montes MG, Orlowski J, Tomazic ML, González Maglio DH, de la Fuente C, Florin-Christensen M, Schnittger L, Nusblat AD. GPI-Anchored Proteomes and Their Biochemical Pathway in Alveolates: Evolutionary Insights and Heterologous Expression in Tetrahymena Thermophila. J Eukaryot Microbiol. 2026 Jan-Feb;73(1):e70055. doi: 10.1111/jeu.70055. PMID: 41355461.
- Mauro Heitrich, Marisa Fernandez, Diana C. Aguilar-Cortes, Santiago Werbajh, Gabriela Canziani, Vanesa Zylberman, Luisina B. Ripari, Guillermo A. Videla-Richardson, Emilio L. Malchiodi, Osvaldo L. Podhajcer, Sabrina E. Vinzon.Development of novel high-affinity nanobodies against EGFR for cancer therapy. bioRxiv doi: https://doi.org/10.1101/2025.03.16.643542, 2025.
CAPÍTULOS DE LIBROS
- How protein deficiency impacts on the response to infection and immunity: the example of helminth parasite infection. Vila CC, Saracino MP, Pallaro AN, Baldi PC. En: Protein Intake in Health and Disease. Preedy VR (Editor). Editorial Taylor and Francis, Reino Unido, 2025. ISBN: 9781032458274
- Rare cases of Human Brucellosis. Wallach JC, García JL, Rey Serantes D, Baldi PC. En: Brucellosis: The Silent Threat to Livestock and Human Health, Capítulo 16. Dadar M (Editora). Editorial Elsevier, Países Bajos, 2025. ISBN: 9780443300677
- Pathogenesis and immunopathological phenomena around Brucella infections. Baldi PC, Ferrero MC, Rodríguez AM, Giambartolomei GH. En: Brucellosis: The Silent Threat to Livestock and Human Health, Capítulo 5. Dadar M (Editora). Editorial Elsevier, Países Bajos, 2025. ISBN: 9780443300677
- Pinazo MJ, Malchiodi E, Ioset JR, Bivona A, Gollob KJ, Dutra WO. Challenges and advancements in the development of vaccines and therapies against Chagas disease. Lancet Microbe. 2024 Oct;5(10):100972. doi: 10.1016/j.lanmic.2024.100972.
- Selener MG, Borgo J, Sarratea MB, Delfino MA, Laurella LC, Cerny N, Gomez J, Coll M, Malchiodi EL, Bivona AE, Barrera P, Redko FC, Catalán CAN, Alberti AS, Sülsen VP. Trypanocidal and Anti-Inflammatory Effects of Three ent-Kaurane Diterpenoids from Gymnocoronis spilanthoides var. subcordata (Asteraceae). Pharmaceutics. 2024 Mar 18;16(3):415. doi: 10.3390/pharmaceutics16030415.
- Elso OG, Cerny N, Laurella LC, Bivona AE, Sánchez Alberti A, Morales C, Catalán CAN, Malchiodi EL, Sülsen VP. In silico toxicologic profile and in vivo trypanocidal activity of estafietin, a sesquiterpene lactone isolated from Stevia alpina Griseb. Nat Prod Res. 2024 Feb-Mar;38(4):690-695. doi: 10.1080/14786419.2023.2188208.
- Welsh JA, Garcia MN, et al. Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J Extracell Vesicles. 2024 Feb;13(2):e12404. doi: 10.1002/jev2.12404.
Zavattieri L, Muñoz González F, Ferrero MC, Baldi PC. Immune Responses Potentially Involved in the Gestational Complications of Brucella Infection. Pathogens. 2023 Dec 14;12(12):1450. https://pubmed.ncbi.nlm.nih.gov/38133333/
Sarratea MB, Alberti AS, Redolfi DM, Truant SN, Iannantuono Lopez LV, Bivona AE, Mariuzza RA, Fernández MM, Malchiodi EL. Zika virus NS4B protein targets TANK-binding kinase 1 and inhibits type I interferon production. Biochim Biophys Acta Gen Subj. 2023 Dec;1867(12):130483. doi: 10.1016/j.bbagen.2023.130483.
Paradise BD, Gainullin VG, Almada LL, Sigafoos AN, Sen S, Vera RE, Raja Arul GL, Toruner M, Pease DR, Gonzalez AL, Mentucci FM, Grasso D, Fernadez-Zapico ME. SUFU promotes GLI activity in a Hedgehog-independent manner in pancreatic cancer. Biochem J. 2023 Aug 16;480(15):1199-1216. doi: 10.1042/BCJ20220439.
Trabucchi A, Bombicino SS, Sabljic AV, Marfía JI, Targovnik AM, Iacono RF, Miranda MV, Valdez SN. Development of an immunoassay for the simultaneous detection of GADA and ZnT8A in autoimmune diabetes using a ZnT8/GAD65 chimeric molecule.Front Immunol. 2023 Aug 3;14:1219857. doi: 10.3389/fimmu.2023.1219857.
Pibuel MA, Poodts D, Sias SA, Byrne A, Hajos SE, Franco PG, Lompardía SL. 4-Methylumbelliferone enhances the effects of chemotherapy on both temozolomide-sensitive and resistant glioblastoma cells. Sci Rep. 2023 Jun 8;13(1):9356. doi: 10.1038/s41598-023-35045-3.
Laurella LC, Elso OG, Rodriguez RN, Viecenz JM, Alonso MR, Bontempi EJ, Malchiodi E, Catalán CAN, Cazorla SI, Sülsen VP. Antiprotozoal compounds from Mikania periplocifolia (Asteraceae). Fitoterapia. 2023 Jun;167:105499. doi: 10.1016/j.fitote.2023.105499.
Alonso Paiva IM, A Santos R, Brito CB, Ferrero MC, Ortiz Wilczyñski JM, Carrera Silva EA, Oliveira SC, Baldi PC. Role of the cGAS/STING pathway in the control of Brucella abortus infection acquired through the respiratory route. Front Immunol. 2023 May 16;14:1116811.
Ledesma M, Poodts D, Amoia S, Hajos S, Fundia A, Vay C, Pibuel M, Lompardía S. Discrimination of the chemotherapy resistance status of human leukemia and glioblastoma cell lines by MALDI-TOF-MS profiling. Sci Rep. 2023 Apr 5;13(1):5596. doi: 10.1038/s41598-023-32608-2.
Borgo J, Elso OG, Gomez J, Coll M, Catalán CAN, Mucci J, Alvarez G, Randall LM, Barrera P, Malchiodi EL, Bivona AE, Martini MF, Sülsen VP. Anti-Trypanosoma cruzi Properties of Sesquiterpene Lactones Isolated from Stevia spp.: In Vitro and In Silico Studies. Pharmaceutics. 2023 Feb 15;15(2):647. doi: 10.3390/pharmaceutics15020647.
Elso OG, Bivona AE, Cenizo R, Malchiodi EL, García Liñares G. Enzymatic synthesis of amlodipine amides and evaluation of their anti-Trypanosoma cruzi activity. Org Biomol Chem. 2023 Feb 15;21(7):1411-1421. doi: 10.1039/d2ob02271k.
Chuluyan E, Davio C, Dusetti N, Fraunhoffer N, Garcia MN, Garona J, González B, Gottardo F, Grasso D, Iovanna J, Kohan G, Lada PE, Mazza O, Monte M, Papademetrio D, Pasqualini ME, Sahores A, Santofimia P, Yaneff A. La vacuna de ARNm para el tratamiento del cáncer de páncreas llegó para quedarse [The mRNA vaccine for the treatment of pancreatic cancer is here to stay]. Medicina (B Aires). 2023;83(4):650-652.
Pibuel MA, Poodts D, Molinari Y, Díaz M, Amoia S, Byrne A, Hajos S, Lompardía S, Franco P. The importance of RHAMM in the normal brain and gliomas: physiological and pathological roles. Br J Cancer. 2023 Jan;128(1):12-20. doi: 10.1038/s41416-022-01999-w.